Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in
finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly …

SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral
replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits …

Transcriptional silencing of HIV in CD4 T cells generates a reservoir of latently infected cells
that can reseed infection after interruption of therapy. As such, these cells represent the …

A long-lived latent reservoir of HIV-1-infected CD4 T cells persists with antiretroviral therapy
and prevents cure. We report that the emergence of latently infected primary CD4 T cells …

Cellular integrated stress response (ISR), the mitochondrial unfolded protein response
(UPRmt), and IFN signaling are associated with viral infections. Activating transcription factor …

Despite the success of antiretroviral therapy, human immunodeficiency virus (HIV) cannot be
cured because of a reservoir of latently infected cells that evades therapy. To understand the …

Background Most of the investigations related to inflammasome activation during HIV
infection have focused on the receptor NLRP3 and innate immune cells such as monocytes …

Although antiretroviral therapy (ART) affects virologic suppression and prolongs life
expectancies among HIV-positive patients; HIV-1-associated neurocognitive disorders …

Background: Accumulating evidence indicates that endoplasmic reticulum (ER) stress plays
a critical role in the regulation of skeletal muscle mass. In recent years, much attention has …