Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

The endothelium forms an important part of the vasculature and is involved in promoting an
atheroprotective environment via the complementary actions of endothelial cell-derived …

Background Pulmonary hypertension is characterized by an increase in vascular tone or an
abnormal proliferation of muscle cells in the walls of small pulmonary arteries. Endothelin-1 …

William harvey, when studying the circulation of the blood, must have recognized that" In
sound and living vessels the blood remains fluid, but it coagulates in dead ones"(Ernst …

▪ Sepsis and its sequelae (sepsis syndrome and septic shock) are increasingly common and
are still potentially lethal diagnoses. Many mediators of the pathogenesis of sepsis have …

Three distinct human endothelin-related genes were cloned by screening a genomic DNA
library under a low hybridization stringency with a synthetic oligonucleotide probe encoding …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …