The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing
weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …