The nucleoplasmic reticulum: form and function
The nuclear envelope (NE) physically separates nucleoplasm and cytoplasm, contributes to
nuclear structural integrity, controls selective bidirectional transport of ions and …
nuclear structural integrity, controls selective bidirectional transport of ions and …
CTP: phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis
CTP: phosphocholine cytidylyltransferase (CCT) catalyzes a rate-limiting and regulated step
in the CDP-choline pathway for the synthesis of phosphatidylcholine (PC) and PC-derived …
in the CDP-choline pathway for the synthesis of phosphatidylcholine (PC) and PC-derived …
Intracellular calcium homeostasis and signaling
Ca 2+ is a universal carrier of biological information: it controls cell life from its origin at
fertilization to its end in the process of programmed cell death. Ca 2+ is a conventional …
fertilization to its end in the process of programmed cell death. Ca 2+ is a conventional …
An update on nuclear calcium signalling
Over the past 15 years or so, numerous studies have sought to characterise how nuclear
calcium (Ca2+) signals are generated and reversed, and to understand how events that …
calcium (Ca2+) signals are generated and reversed, and to understand how events that …
Crosstalk between calcium and redox signaling: from molecular mechanisms to health implications
Studies done many years ago established unequivocally the key role of calcium as a
universal second messenger. In contrast, the second messenger roles of reactive oxygen …
universal second messenger. In contrast, the second messenger roles of reactive oxygen …
[HTML][HTML] The endoplasmic reticulum and junctional membrane communication during calcium signaling
The endoplasmic reticulum is a major organelle in all eukaryotic cells which performs
multiple functions including protein and lipid synthesis and sorting, drug metabolism, and Ca …
multiple functions including protein and lipid synthesis and sorting, drug metabolism, and Ca …
High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry
F Cerignoli, D Charlot, R Whittaker… - … of pharmacological and …, 2012 - Elsevier
Current methods to measure physiological properties of cardiomyocytes and predict fatal
arrhythmias that can cause sudden death, such as Torsade de Pointes, lack either the …
arrhythmias that can cause sudden death, such as Torsade de Pointes, lack either the …
Dantrolene enhances antisense-mediated exon skip** in human and mouse models of Duchenne muscular dystrophy
GC Kendall, EI Mokhonova, M Moran… - Science translational …, 2012 - science.org
Duchenne muscular dystrophy (DMD) causes profound and progressive muscle weakness
and loss, resulting in early death. DMD is usually caused by frameshifting deletions in the …
and loss, resulting in early death. DMD is usually caused by frameshifting deletions in the …
Alzheimer's disease: An acquired neurodegenerative laminopathy
The nucleus is typically depicted as a sphere encircled by a smooth surface of nuclear
envelope. For most cell types, this depiction is accurate. In other cell types and in some …
envelope. For most cell types, this depiction is accurate. In other cell types and in some …
Behind the stoNE wall: A fervent activity for nuclear lipids
K Samardak, J Bâcle, M Moriel-Carretero - Biochimie, 2024 - Elsevier
The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …
The knowledge about their respective interactions is as important as the individual …