Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Both laboratory investigations and body composition quantification measures (eg, computed
tomography, CT) portray muscle loss in symptomatic Coronavirus disease 2019 (COVID-19) …

The soluble receptor for advanced glycation end-products (sRAGE) has been classically
considered a sink for pro-inflammatory RAGE ligands and as such has been associated with …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Alzheimer's disease (AD) is the most common form of dementia characterized by
progressive memory loss and cognitive decline. Although neuroinflammation and oxidative …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …