Recent advances in user-friendly computational tools to engineer protein function

CE Sequeiros-Borja, B Surpeta… - Briefings in …, 2021 - academic.oup.com
Progress in technology and algorithms throughout the past decade has transformed the field
of protein design and engineering. Computational approaches have become well-engrained …

Ca2+ binding to F‐ATP synthase β subunit triggers the mitochondrial permeability transition

V Giorgio, V Burchell, M Schiavone, C Bassot… - EMBO …, 2017 - embopress.org
F‐ATP synthases convert the electrochemical energy of the H+ gradient into the chemical
energy of ATP with remarkable efficiency. Mitochondrial F‐ATP synthases can also undergo …

In silico approaches to investigate enzyme immobilization: a comprehensive systematic review

F Barati, F Hosseini, R Vafaee, Z Sabouri… - Physical Chemistry …, 2024 - pubs.rsc.org
Enzymes are popular catalysts with many applications, especially in industry. Biocatalyst
usage on a large scale is facing some limitations, such as low operational stability, low …

[HTML][HTML] Omicron coronavirus: pH-dependent electrostatic potential and energy of association of spike protein to ACE2 receptor

SH Hristova, AM Zhivkov - Viruses, 2023 - mdpi.com
The association of the S-protein of the SARS-CoV-2 beta coronavirus to ACE2 receptors of
the human epithelial cells determines its contagiousness and pathogenicity. We computed …

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses

M Zamora, E Méndez-López, X Agirrezabala… - Science …, 2017 - science.org
Potyviruses constitute the second largest genus of plant viruses and cause important
economic losses in a large variety of crops; however, the atomic structure of their particles …

Bioorthogonal catalytic activation of platinum and ruthenium anticancer complexes by FAD and flavoproteins

S Alonso‐de Castro, AL Cortajarena… - Angewandte …, 2018 - Wiley Online Library
Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for
performing chemoselective transformations in complex biological environments. Herein, we …

Intraparticle macromolecular migration alters the structure and function of proteins reversibly immobilized on porous microbeads

E Diamanti, S Arana‐Peña… - Advanced Materials …, 2022 - Wiley Online Library
While migration of reversibly immobilized proteins across the volume of supports is
investigated in conditions where an external force is applied or under fluid flow conditions …

Structure of Turnip mosaic virus and its viral-like particles

R Cuesta, C Yuste-Calvo, D Gil-Cartón, F Sánchez… - Scientific Reports, 2019 - nature.com
Turnip mosaic virus (TuMV), a potyvirus, is a flexible filamentous plant virus that displays a
helical arrangement of coat protein copies (CPs) bound to the ssRNA genome. TuMV is a …

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin

PP Mangione, G Esposito, A Relini, S Raimondi… - Journal of Biological …, 2013 - jbc.org
Systemic amyloidosis is a fatal disease caused by misfolding of native globular proteins,
which then aggregate extracellularly as insoluble fibrils, damaging the structure and function …

PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods

T Lebek, M Malaguti, GLM Boezio, L Zoupi… - The EMBO …, 2024 - embopress.org
Cell communication coordinates developmental processes, maintains homeostasis, and
contributes to disease. Therefore, understanding the relationship between cells in a shared …