Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

The intranasal (IN) route enables the delivery of insulin to the central nervous system in the
relative absence of systemic uptake and related peripheral side effects. Intranasally …

Brain function relies almost solely on glucose as an energy substrate. The main model of
brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes …

Brain insulin resistance links the failure of energy metabolism with cognitive decline in both
type 2 Diabetes Mellitus (T2D) and Alzheimer's disease (AD), although the molecular …

Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the
development and maintenance of neurons in the brain, and in humans neurodevelopmental …

This review provides a qualitative and quantitative analysis of cerebral glucose metabolism
in ageing. We undertook a systematic literature review followed by pooled effect size and …

Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with
Alzheimer's disease (AD). This is partly due to insulin resistance in the brain. Insulin …

Introduction Rigorous research in the last few years has shown that in addition to the
classical mechanism of neurodegeneration, certain unconventional mechanisms may also …

Abstract Background/Objectives Intranasal (IN) administration of insulin decreases appetite
in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin …