Mechanisms of regulation of the chemokine-receptor network
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …
of leukocytes during normal immune function and as a key aspect of the inflammatory …
Invited review: Activation of G proteins by GTP and the mechanism of Gα‐catalyzed GTP hydrolysis
This review addresses the regulatory consequences of the binding of GTP to the alpha
subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis …
subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis …
Gi/o protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission
G protein‐coupled receptors (GPCRs) play key roles in intercellular signaling in the brain.
Their effects on cellular function have been largely studied in neurons, but their functional …
Their effects on cellular function have been largely studied in neurons, but their functional …
RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
Background Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6)
translocates to the nucleolus in response to cytotoxic stress though the functional …
translocates to the nucleolus in response to cytotoxic stress though the functional …
[HTML][HTML] Broadening horizons: exploring mtDAMPs as a mechanism and potential intervention target in cardiovascular diseases
Y Luan, Y Luan, Y Jiao, H Liu, Z Huang… - Aging and …, 2023 - pmc.ncbi.nlm.nih.gov
Cardiovascular diseases (CVDs) have been recognized as the leading cause of premature
mortality and morbidity worldwide despite significant advances in therapeutics. Inflammation …
mortality and morbidity worldwide despite significant advances in therapeutics. Inflammation …
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-
coding regions, hampering their functional interpretation. Instead, transcriptome-wide …
coding regions, hampering their functional interpretation. Instead, transcriptome-wide …
Control of adipogenesis by oxylipins, GPCRs and PPARs
Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6
polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase …
polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase …
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice
Background and Purpose Drugs of abuse, including alcohol, increase dopamine in the
mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area …
mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area …
[HTML][HTML] RGS14 regulation of post-synaptic signaling and spine plasticity in brain
NH Harbin, SN Bramlett, C Montanez-Miranda… - International Journal of …, 2021 - mdpi.com
The regulator of G-protein signaling 14 (RGS14) is a multifunctional signaling protein that
regulates post synaptic plasticity in neurons. RGS14 is expressed in the brain regions …
regulates post synaptic plasticity in neurons. RGS14 is expressed in the brain regions …
Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol
Abstract Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute
lymphoblastic leukemia treatment. Among 1285 children (1.0–17.9 years) diagnosed during …
lymphoblastic leukemia treatment. Among 1285 children (1.0–17.9 years) diagnosed during …