Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Vascular calcification: from pathophysiology to biomarkers

S Evrard, P Delanaye, S Kamel, JP Cristol, E Cavalier… - Clinica chimica acta, 2015 - Elsevier
The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

Osteopontin–a multi-modal marker and mediator in atherosclerotic vascular disease

T Wolak - Atherosclerosis, 2014 - Elsevier
Atherosclerosis is a chronic inflammatory process of the vessel wall with systemic correlates.
It is now well established that patients' outcome is tightly linked to atherosclerotic plaque …

The effect of PCSK9 inhibition on the stabilization of atherosclerotic plaque determined by biochemical and diagnostic imaging methods

M Basiak, M Hachula, M Kosowski, G Machnik… - Molecules, 2023 - mdpi.com
Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound
and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque …

Bone loss and vascular calcification: a bi-directional interplay?

C Vassalle, A Mazzone - Vascular pharmacology, 2016 - Elsevier
Vascular calcification (VC) represents a recognized adverse predictor for cardiovascular
morbidity and mortality. Previously considered passive and degenerative, VC is now …

Association of serum levels of osteopontin and osteoprotegerin with adverse outcomes after endovascular revascularisation in peripheral artery disease

NPE Kadoglou, D Kapetanios, E Korakas… - Cardiovascular …, 2022 - Springer
Background Osteoprotegerin (OPG) and osteopontin (OPN) are vascular calcification
inhibitors with a known role in the atherosclerotic and inflammatory process. We investigated …

Circulating osteopontin as a marker of early coronary vascular calcification in type two diabetes mellitus patients with known asymptomatic coronary artery disease

AE Berezin, AA Kremzer - Atherosclerosis, 2013 - Elsevier
Objective To evaluate the interrelation between circulating osteopontin (OPN) and coronary
atherosclerosis and calcification in type 2 diabetes mellitus patients (T2DM). Design and …

Biomarkers of vascular calcification in serum

S Roumeliotis, A Roumeliotis, E Dounousi… - Advances in clinical …, 2020 - Elsevier
Over the last decades, the association between vascular calcification (VC) and all-
cause/cardiovascular mortality, especially in patients with high atherogenic status, such as …

Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in patients with type 1 diabetes

D Gordin, C Forsblom, NM Panduru… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Osteopontin (OPN) is a multifunctional protein suggested to be a player in the
arterial disease of patients with type 2 diabetes. However, its role for complications in …

miR-145 improves metabolic inflammatory disease through multiple pathways

M He, N Wu, MC Leong, W Zhang, Z Ye… - Journal of molecular …, 2020 - academic.oup.com
Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes, yet the
mechanisms are not completely understood. Here, we demonstrated that serum LPS levels …