The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Abstract Background N6-methyladenosine (m 6 A) modification is known to impact many
aspects of RNA metabolism, including mRNA stability and translation, and is highly …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

Emergence of form and function during embryogenesis arises in large part through cell-type-
and cell-state-specific variation in gene expression patterns, mediated by specialized cis …

Motivation: DNA methylation is an epigenetic modification with important roles in many
biological processes and diseases. Bisulfite sequencing (BS-seq) has emerged recently as …