An update into the medicinal chemistry of translocator protein (TSPO) ligands
Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
Translocator protein in the rise and fall of central nervous system neurons
Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane,
has historically been associated with the transport of cholesterol in highly steroidogenic …
has historically been associated with the transport of cholesterol in highly steroidogenic …
TSPO ligands boost mitochondrial function and pregnenolone synthesis
Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and
plays an important role in steroidogenesis and cell survival. In the central nervous system …
plays an important role in steroidogenesis and cell survival. In the central nervous system …
Mitochondria as a promising target for develo** novel agents for treating Alzheimer's disease
EF Shevtsova, AV Maltsev… - Medicinal Research …, 2021 - Wiley Online Library
The mitochondria‐targeting drugs can be conventionally divided into the following groups:
those compensating for the energy deficit involved in neurodegeneration, including …
those compensating for the energy deficit involved in neurodegeneration, including …
Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1
I Marginedas-Freixa, CL Alvarez, M Moras… - Scientific reports, 2018 - nature.com
We previously demonstrated that the translocase protein TSPO2 together with the voltage-
dependent anion channel (VDAC) and adenine nucleotide transporter (ANT) were involved …
dependent anion channel (VDAC) and adenine nucleotide transporter (ANT) were involved …
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …
Neurosteroids and Translocator Protein (TSPO) in neuroinflammation.
E Angeloni, L Germelli, B Costa, C Martini… - Neurochemistry …, 2024 - Elsevier
Neurosteroids have a crucial role in physiological intrinsic regulations of the Central
Nervous System functions. They are derived from peripheral steroidogenic sources and from …
Nervous System functions. They are derived from peripheral steroidogenic sources and from …
Electrochemical dual oxidative C (sp 3)–H amination: switchable synthesis of imidazo-fused quinazolinones
C Du, Y Zhang, T Li, Z Zha, Z Wang - Chemical Communications, 2024 - pubs.rsc.org
An efficient electrochemical dual C (sp3)–H amination was developed under metal-free and
chemical oxidant-free conditions. A series of imidazo [1, 5-a] quinazolin-5 (4H)-ones and 5 …
chemical oxidant-free conditions. A series of imidazo [1, 5-a] quinazolin-5 (4H)-ones and 5 …
Development of new treatments for Alzheimer's disease based on the modulation of translocator protein (TSPO)
BD Arbo, MF Ribeiro, LM Garcia-Segura - Ageing research reviews, 2019 - Elsevier
The increase in life expectancy of the world population is associated with a higher
prevalence of neurodegenerative diseases. Alzheimer's Disease (AD) is the most common …
prevalence of neurodegenerative diseases. Alzheimer's Disease (AD) is the most common …
Iridium-catalyzed enantioselective synthesis of dihydroimidazoquinazolinones by elaborate tuning of chiral cyclic ligands
F Peng, H Tian, P Zhang, C Liu, X Wu, X Yuan… - Organic …, 2017 - ACS Publications
A highly efficient, enantioselective intramolecular allylation of (E)-4-(alkyl (4-oxo-3, 4-
dihydroquinazolin-2-yl) amino) but-2-en-1-yl methyl carbonates was developed, and the …
dihydroquinazolin-2-yl) amino) but-2-en-1-yl methyl carbonates was developed, and the …