One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

In the olfactory system of Drosophila melanogaster, it is relatively straightforward to target in
vivo measurements of neural activity to specific processing channels. This, together with the …

To sense myriad environmental odors, animals have evolved multiple, large families of
divergent olfactory receptors. How and why distinct receptor repertoires and their associated …

The rate of action potential firing in nociceptors is a major determinant of the intensity of
pain. Possible modulators of action potential firing include the HCN ion channels, which …

Local interneurons are essential in information processing by neural circuits. Here we
present a comprehensive genetic, anatomical and electrophysiological analysis of local …

Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a
mystery, although recent work suggests that sleep, memory, and plasticity are linked …

A striking commonality across insects and vertebrates is the recurring presence of parallel
olfactory subsystems, suggesting that such an organization has a highly adaptive value …

In both insect and vertebrate olfactory systems only two synapses separate the sensory
periphery from brain areas required for memory formation and the organisation of behaviour …

The ability of organisms to seamlessly ignore familiar, inconsequential stimuli improves their
selective attention and response to salient features of the environment. Here, I propose that …

Olfactory glomeruli are morphologically conserved spherical compartments of the olfactory
system, distinguishable solely by their chemosensory repertoire, anatomical position, and …