Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Cell-cell interactions and cell adhesion are key mediators of cancer progression and
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …

Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …

The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …

Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of
biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest …

Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

Ischemic stroke, caused by a sudden disruption of blood flow to the brain, is a leading cause
of death and exerts a heavy burden on both patients and public health systems. Currently …

Cell responses to the extracellular matrix depend on specific signaling events. These are
important from early development, through differentiation and tissue homeostasis, immune …