Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood
glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for
cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C …

ABCA1 functions as a lipid transporter because it mediates the transfer of cellular
phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Because cholesterol is a precursor for the synthesis of steroid hormones, steroidogenic
tissues have evolved multiple pathways to ensure adequate supplies of cholesterol. These …

The removal of excess free cholesterol from cells by HDL or its apolipoproteins is important
for maintaining cellular cholesterol homeostasis. This process is most likely compromised in …

The concentration, composition, shape, and size of plasma high-density lipoprotein (HDL)
are determined by numerous proteins that influence its biogenesis, remodeling, and …

ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular
phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process …

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …