Complex diseases such as cardiovascular disease (CVD), obesity, inflammatory bowel
disease (IBD), kidney disease, type 2 diabetes (T2D), and cancer have become a major …

Riboflavin is widely regarded as an essential nutrient that is involved in biological oxidation
in vivo. In addition to preventing and treating acyl-CoA dehydrogenase deficiency in patients …

Spontaneous abortion is a pregnancy complication characterized by complex and
multifactorial etiology. About 5% of childbearing women are globally affected by early …

Recent advances in epigenetic research have enabled the development of epigenetic
clocks, which have greatly enhanced our ability to investigate molecular processes that …

S-Adenosylmethionine (SAM) is the primary methyl donor for numerous cellular methylation
reactions. Its central role in methylation and involvement with many pathways link its …

Renal disease is the common denominator of a number of underlying disease conditions,
whose prevalence has been dramatically increasing over the last two decades. Two aspects …

Background: High blood pressure is the main cause of cardiovascular diseases. Kidney
damage is one of the most common organ secondary damage to hypertension. The study of …

Humans operating in extreme environments often conduct their operations at the edges of
the limits of human performance. Sometimes, they are required to push these limits to …

Background The interaction between genetic, epigenetic and environmental factors plays an
important role in the aetiology of hypertension. GWAS and observational studies link the …

Background The aetio-pathologenesis of hypertension is multifactorial, encompassing
genetic, epigenetic, and environmental factors. The combined effect of genetic and …