Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Genomic footprinting has emerged as an unbiased discovery method for transcription factor
(TF) occupancy at cognate DNA in vivo. A basic premise of footprinting is that sequence …

A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …

The eukaryotic genome is packaged into a periodic nucleoprotein structure termed
chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound …

Chromatin-remodeling complexes regulate access to nucleosomal DNA by mobilizing
nucleosomes in an ATP-dependent manner. In this study, we find that chromatin remodeling …

ISWI-family enzymes remodel chromatin by sliding nucleosomes along DNA, but the
nucleosome translocation mechanism remains unclear. Here we use single-molecule FRET …

The structure of the SWI/SNF-remodeled nucleosome was characterized with single base-
pair resolution by map** the contacts of specific histone fold residues with nucleosomal …