[HTML][HTML] Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma

FH Kong, QF Ye, XY Miao, X Liu, SQ Huang, L **ong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the
leading causes of cancer-related death worldwide. Advanced HCC displays strong …

Obesity and cancer pathogenesis

NA Berger - Annals of the New York Academy of Sciences, 2014 - Wiley Online Library
Overweight and obesity have reached pandemic levels on a worldwide basis and are
associated with increased risk and worse prognosis for many but not all malignancies …

Association of obesity with survival outcomes in patients with cancer: a systematic review and meta-analysis

F Petrelli, A Cortellini, A Indini, G Tomasello… - JAMA network …, 2021 - jamanetwork.com
Importance Obesity, defined as a body mass index (BMI) greater than 30, is associated with
a significant increase in the risk of many cancers and in overall mortality. However, various …

Appropriate systemic therapy dosing for obese adult patients with cancer: ASCO guideline update

JJ Griggs, K Bohlke, EP Balaban, JJ Dignam… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE To provide recommendations for appropriate dosing of systemic antineoplastic
agents in obese adults with cancer. METHODS A systematic review of the literature collected …

Sorafenib-loaded PLGA carriers for enhanced drug delivery and cellular uptake in liver cancer cells

TM Caputo, AM Cusano, S Principe… - International Journal …, 2023 - Taylor & Francis
Introduction Currently, conventional treatments of hepatocellular carcinoma (HCC) are not
selective enough for tumor tissue and lead to multidrug resistance and drug toxicity …

Sex and gender differences in anticancer treatment toxicity: a call for revisiting drug dosing in oncology

BC Özdemir, CL Gerard, C Espinosa da Silva - Endocrinology, 2022 - academic.oup.com
The practice of oncology has dramatically changed in the last decade with the introduction of
molecular tumor profiling into routine tumor diagnostics and the extraordinary progress in …

Obesity and breast cancer: not only a risk factor of the disease

DSM Chan, T Norat - Current treatment options in oncology, 2015 - Springer
Opinion statement Obesity not only is an independent risk factor of postmenopausal breast
cancer (BC), and in particular estrogen receptor-positive/progesterone receptor-positive BC …

Messing up the cancer stem cell chemoresistance mechanisms supported by tumor microenvironment

M Gaggianesi, S Di Franco, VD Pantina… - Frontiers in …, 2021 - frontiersin.org
Despite the recent advances in cancer patient management and in the development of
targeted therapies, systemic chemotherapy is currently used as a first-line treatment for …

The challenges of treating patients with breast cancer and obesity

A LeVee, J Mortimer - Cancers, 2023 - mdpi.com
Simple Summary Obesity is a poor prognostic factor for patients with breast cancer, resulting
in increased risk of recurrence and death due to breast cancer. Obesity can affect both the …

Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma

F Chen, Y Fang, R Zhao, J Le, B Zhang… - European Journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …