Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases
G Wigerblad, MJ Kaplan - Nature Reviews Immunology, 2023 - nature.com
Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …
differentiate self from non-self. These conditions are associated with significant morbidity …
The neutrophil's role during health and disease
Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …
DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
Neutrophils in COVID-19
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …
neutrophils play an important role in the pathophysiology, particularly in those with severe …
[HTML][HTML] Co-option of neutrophil fates by tissue environments
Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …
in their fast and moldable response to stimulation. This plastic behavior may underlie …
Heterogeneity of neutrophils
Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …
for a renewed understanding of the biology of immune cells, such as macrophages and …
Patrolling alveolar macrophages conceal bacteria from the immune system to maintain homeostasis
AS Neupane, M Willson, AK Chojnacki… - Cell, 2020 - cell.com
During respiration, humans breathe in more than 10,000 liters of non-sterile air daily,
allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar …
allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar …
The neutrophil life cycle
Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …
Strategies of neutrophil diversification
Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …
Programmed 'disarming'of the neutrophil proteome reduces the magnitude of inflammation
JM Adrover, A Aroca-Crevillén, G Crainiciuc… - Nature …, 2020 - nature.com
The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of
proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs) …
proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs) …