Intravascular blood clots form in an environment in which hydrodynamic forces dominate
and in which fluid-mediated transport is the primary means of moving material. The clotting …

Single polymer dynamics offers a powerful approach to study molecular-level interactions
and dynamic microstructure in materials. Direct visualization of single polymer chains has …

Protein molecules are subjected to potentially denaturing fluid shear forces during
processing and in circulation in the body. These complex molecules, involved in numerous …

There is concern that shear could cause protein unfolding or aggregation during commercial
biopharmaceutical production. In this work we exposed two concentrated immunoglobulin …

The unfolding of von Willebrand Factor (vWF), one of the largest multimeric proteins in our
body, has been shown to be a crucial step in the process of blood clotting. Here we show …

Abstract von Willebrand factor (VWF) is a multimeric blood protein that acts as a mechanical
probe, responding to changes in flow to initiate platelet plug formation. Previously, our …

Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

Abstract Tissue-equivalents (TEs), simple model tissues with tunable properties, have been
used to explore many features of biological soft tissues. Absent in most formulations …

Blood clotting is a process by which a haemostatic plug is assembled at the site of injury.
The formation of such a plug, which is essentially a (bio) polymer–colloid composite, is …

The behavior of linear polymer chains in dilute solution flows has an established history.
Polymers often possess more complex architectures, however, such as branched, dendritic …