The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

In the review we analyzed short history of the establishment of a novel hematological
parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio …

Systemic inflammation markers have been linked to increased cancer risk and mortality in a
number of studies. However, few studies have estimated pre-diagnostic associations of …

The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …