Bioinformatics pipelines are essential in the analysis of genomic and transcriptomic data
generated by next-generation sequencing (NGS). Recent guidelines emphasize the need …

Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

RNA-Seq made possible the global identification of fusion transcripts, ie “chimeric RNAs”.
Even though various software packages have been developed to serve this purpose, they …

Genomic instability is a hallmark of cancer and, as such, structural alterations and fusion
genes are common events in the cancer landscape. RNA sequencing (RNA-Seq) is a …

Lung cancer is emerging as a paradigm for disease molecular subty**, facilitating
targeted therapy based on driving somatic alterations. Here we perform transcriptome …

Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …

Abstract Analysis of RNA-seq data often detects numerous 'non-co-linear'(NCL) transcripts,
which comprised sequence segments that are topologically inconsistent with their …

Massively parallel RNA sequencing (RNA-seq) has rapidly become the assay of choice for
interrogating RNA transcript abundance and diversity. This article provides a detailed …

Fusion transcripts (ie, chimeric RNAs) resulting from gene fusions have been used
successfully for cancer diagnosis, prognosis, and therapeutic applications. In addition, many …

Chromosomal rearrangement and genome instability are common features of cancer cells in
human. Consequently, gene duplication and gene fusion events are frequently observed in …