Cell death can be classified according to the morphological appearance of the lethal
process (that may be apoptotic, necrotic, autophagic or associated with mitosis) …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting
molecules, formation of the death inducing signaling complex and the role of caspases …

The sphingomyelin (SM) pathway is a ubiquitous, evolutionarily conserved signalling system
analogous to conventional systems such as the cAMP and phosphoinositide pathways …

La céramide, un nouveau second messager et lipide bioactif, est principalement formée lors
de l'hydrolyse de la sphingomyéline par des sphingomyélinases. Au moins deux …

The physiological role of ceramide formation in response to cell stimulation remains
controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling …

Ceramide has been recognized as a common intracellular second messenger for various
cytokines, growth factors and other stimuli, such as CD95, chemotherapeutic drugs and …

Glycolipids such as ganglioside GM1 are involved in the building of carbohydrate layers on
the surface of living cells. The investigation of the metabolism of this class of compounds …

Recent studies suggest that trimerization of Fas is insufficient for apoptosis induction and
indicate that super-aggregation of trimerized Fas might be prerequisite. For many cell …

The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as
FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these …