During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …

Research on the human microbiome has yielded numerous insights into health and disease,
but also has resulted in a wealth of experimental artifacts. Here, we present suggestions for …

Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that
somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) …

Genome-wide epigenomic maps have revealed millions of putative enhancers and
promoters, but experimental validation of their function and high-resolution dissection of …

Schizophrenia (SCZ) is a highly heritable mental disorder with thousands of associated
genetic variants located mostly in the noncoding space of the genome. Translating these …

Non-coding transcriptional regulatory elements are critical for controlling the spatiotemporal
expression of genes. Here, we demonstrate that the sizes and number of enhancers linked …