Cytoskeleton organization in formation and motility of apicomplexan parasites

RG Douglas, RW Moon… - Annual Review of …, 2024 - annualreviews.org
Apicomplexan parasites are a group of eukaryotic protozoans with diverse biology that have
affected human health like no other group of parasites. These obligate intracellular parasites …

γ-tubulin complex controls the nucleation of tubulin-based structures in Apicomplexa

R Haase, A Puthenpurackal, B Maco… - Molecular Biology of …, 2024 - molbiolcell.org
Apicomplexan parasites rely on tubulin structures throughout their cell and life cycles,
particularly in the polymerization of spindle microtubules to separate the replicated nucleus …

Toxoplasma gondii rhoptry discharge factor 3 is essential for invasion and microtubule-associated vesicle biogenesis

R Ben Chaabene, M Martinez, A Bonavoglia… - Plos …, 2024 - journals.plos.org
Rhoptries are specialized secretory organelles conserved across the Apicomplexa phylum,
essential for host cell invasion and critical for subverting of host cellular and immune …

Recent advances in identifying and characterizing secretory proteins of Toxoplasma gondii by CRISPR-based screening

Y Tachibana, M Yamamoto - Parasitology International, 2024 - Elsevier
The apicomplexan parasite, Toxoplasma gondii, develops unique secretory organelles,
such as micronemes, rhoptries, and dense granules, which do not exist in other well-studied …

Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion

B Ren, R Haase, S Patray, Q Nguyen, B Maco… - Proceedings of the …, 2024 - pnas.org
In Toxoplasma gondii, the conoid comprises a cone with spiraling tubulin fibers, preconoidal
rings, and intraconoidal microtubules. This dynamic organelle undergoes extension and …

Mo squito Tiss ue U ltrastructure-E xpansion M icroscopy (MoTissU-ExM) enables ultrastructural and anatomical analysis of malaria parasites and their mosquito

B Liffner, TLA Silva, J Vega-Rodriguez, S Absalon - BMC Methods, 2024 - Springer
Background Study of malaria parasite cell biology is challenged by their small size, which
can make visualisation of individual organelles difficult or impossible using conventional …

RNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii: a key mechanism in parasite motility and invasion

R Haase, B Ren, ND Santos Pacheco, R Visentin… - bioRxiv, 2024 - biorxiv.org
In Toxoplasma gondii, the conoid is a dynamic organelle composed of spiraling tubulin
fibers that extrudes during egress, gliding motility, and invasion. This organelle traverses the …

Ultrastructure expansion microscopy: Enlarging our perspective on apicomplexan cell division

S Horjales, F Sena, ME Francia - Journal of Microscopy, 2025 - Wiley Online Library
Apicomplexans, a large phylum of protozoan intracellular parasites, well known for their
ability to invade and proliferate within host cells, cause diseases with major health and …

Multifaceted Dinoflagellates and the Marine Model Prorocentrum cordatum

J Kalvelage, R Rabus - Microbial Physiology, 2024 - karger.com
Background: Dinoflagellates are a monophyletic group within the taxon Alveolata, which
comprises unicellular eukaryotes. Dinoflagellates have long been studied for their …

Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex

AT i Puig, D Soldati-Favre - Trends in Parasitology, 2024 - cell.com
Microtubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The
phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the …