ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

Ferroptosis is a necrotic form of iron‐dependent regulatory cell death. Estrogen withdrawal
can interfere with iron metabolism, which is responsible for the pathogenesis of …

The Bloom syndrome (BLM) helicase is critical for alternative lengthening of telomeres
(ALT), a homology-directed repair (HDR)-mediated telomere maintenance mechanism that …

In recent years, significant advances have been made in understanding the intricate details
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

DAXX and ATRX are tumor suppressor proteins that form a histone H3. 3 chaperone
complex and are frequently mutated in cancers with the alternative lengthening of telomeres …

Simple Summary ATRX is one of the most frequently mutated tumor suppressor genes in
human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is …