Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

YQ He, CC Zhou, LY Yu, L Wang, J Deng… - Pharmacological …, 2021 - Elsevier
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS) as common life-threatening lung diseases with high mortality rates are mostly …

[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway

J Tang, L Xu, Y Zeng, F Gong - International immunopharmacology, 2021 - Elsevier
Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal
microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored …

Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019: the …

SG Deftereos, G Giannopoulos, DA Vrachatis… - JAMA network …, 2020 - jamanetwork.com
Importance Severe acute respiratory syndrome coronavirus 2 infection has evolved into a
global pandemic. Low-dose colchicine combines anti-inflammatory action with a favorable …

An immune-cell signature of bacterial sepsis

M Reyes, MR Filbin, RP Bhattacharyya, K Billman… - Nature medicine, 2020 - nature.com
Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …

Interleukin‐18: Biological properties and role in disease pathogenesis

G Kaplanski - Immunological reviews, 2018 - Wiley Online Library
Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …

Acute lung injury: a clinical and molecular review

Y Butt, A Kurdowska, TC Allen - Archives of Pathology …, 2016 - meridian.allenpress.com
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of
lung changes arising from a wide variety of lung injuries, frequently resulting in significant …

[HTML][HTML] Sepsis: evolving concepts and challenges

R Salomão, BL Ferreira, MC Salomão… - Brazilian Journal of …, 2019 - SciELO Brasil
Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

Ventilator-induced lung injury

JR Beitler, A Malhotra… - Clinics in chest …, 2016 - chestmed.theclinics.com
As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Biomarkers for acute respiratory distress syndrome and prospects for personalised medicine

S Spadaro, M Park, C Turrini, T Tunstall… - Journal of …, 2019 - Springer
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …