Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review

Z Fu, PY Zhao, XP Yang, H Li, SD Hu, YX Xu… - Frontiers in …, 2023 - frontiersin.org
Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used
in the treatment of mental disorders because of its antidepressive, anxiolytic, and …

Discovery of NAFLD-improving agents by promoting the degradation of Keap1

M Qi, H Zhong, Z Cheng, S Chen, H **ao… - Journal of Medicinal …, 2023 - ACS Publications
Activating Nrf2 through inhibiting Keap1 has been proven to alleviate oxidative stress and
related diseases, including nonalcoholic fatty liver disease (NAFLD). Traditional Keap1 …

[HTML][HTML] Decreasing the burden of non-alcoholic fatty liver disease: From therapeutic targets to drug discovery opportunities

R Amorim, P Soares, D Chavarria, S Benfeito… - European Journal of …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) presents a pervasive global pandemic, affecting
approximately 25% of the world's population. This grave health issue not only demands …

Endoplasmic reticulum-mitochondrial calcium transport contributes to soft extracellular matrix-triggered mitochondrial dynamics and mitophagy in breast carcinoma …

Y Chen, P Li, X Chen, R Yan, Y Zhang, M Wang, X Qin… - Acta Biomaterialia, 2023 - Elsevier
Although mitochondrial morphology and function are considered to be closely related to
matrix stiffness-driven tumor progression, it remains poorly understood how extracellular …

Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases

L Wang, X Fang, B Ling, F Wang, Y **a… - Frontiers in Cellular …, 2024 - frontiersin.org
Globally, millions of individuals are impacted by neurodegenerative disorders including
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) …

6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice

K Gong, Z Zhang, S Chen, X Zhu, M Wang… - Acta Pharmacologica …, 2023 - nature.com
Excessive fructose consumption increases hepatic de novo lipogenesis, resulting in cellular
stress, inflammation and liver injury. Nogo-B is a resident protein of the endoplasmic …

Exercise is medicine for nonalcoholic fatty liver disease: exploration of putative mechanisms

JW Heinle, K DiJoseph, A Sabag, S Oh, SR Kimball… - Nutrients, 2023 - mdpi.com
Exercise remains a key component of nonalcoholic fatty liver disease (NAFLD) treatment.
The mechanisms that underpin improvements in NAFLD remain the focus of much …

Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in non-alcoholic fatty liver disease

TE Maseko, M Elkalaf, E Peterová… - International …, 2023 - spandidos-publications.com
Although some clinical studies have reported increased mitochondrial respiration in patients
with fatty liver and early non-alcoholic steatohepatitis (NASH), there is a lack of in vitro …

[HTML][HTML] Alginate Oligosaccharides Enhance Antioxidant Status and Intestinal Health by Modulating the Gut Microbiota in Weaned Piglets

M Liu, X Deng, Y Zhao, N Everaert, H Zhang… - International Journal of …, 2024 - mdpi.com
Alginate oligosaccharides (AOSs), which are an attractive feed additive for animal
production, exhibit pleiotropic bioactivities. In the present study, we investigated graded …