Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the
transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK …

Over the past decade, rapid advances in genomics, proteomics and functional genomics
technologies that enable in-depth interrogation of cancer genomes and proteomes and high …

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Protein kinase CK2 (designated CSNK2) is a constitutively active protein kinase with a vast
repertoire of putative substrates that has been implicated in several human cancers …

One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to
profile genetic dependencies in cancer cell lines. Here, we describe data from a series of …

The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …

Mirror-image proteins, composed of d-amino acids, are an attractive therapeutic modality, as
they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image …

Protein kinases are essential for signal transduction and control of most cellular processes,
including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of …

TRAIL/Apo-2L is a member of the TNF superfamily first described as an apoptosis-inducing
cytokine in 1995. Similar to TNF and Fas ligand, TRAIL induces apoptosis in caspase …