Spatiotemporal omics for biology and medicine
The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …
understanding human life. Nonetheless, understanding the intricate mechanisms through …
Central role for cholangiocyte pathobiology in cholestatic liver diseases
N Jalan-Sakrikar, ME Guicciardi, SP O'Hara, A Azad… - Hepatology, 2024 - journals.lww.com
Cholangiopathies comprise a spectrum of chronic intra-and extrahepatic biliary tract
disorders culminating in progressive cholestatic liver injury, fibrosis and often cirrhosis and …
disorders culminating in progressive cholestatic liver injury, fibrosis and often cirrhosis and …
A spatiotemporal atlas of mouse liver homeostasis and regeneration
The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …
homeostasis and perturbation is poorly understood, representing a major obstacle in our …
Mdka produced by the activated hepatic stellate cells drives bipotential progenitor cell redifferentiation during zebrafish biliary-mediated liver regeneration
X Zhang, H Liu, P Cai, Z Huang, J Ma, L Luo - Hepatology, 2024 - journals.lww.com
Conclusions: The activated HSCs produce Mdka to drive the redifferentiation process of BP-
PCs through activating Erk1 during the biliary-mediated liver regeneration, implying …
PCs through activating Erk1 during the biliary-mediated liver regeneration, implying …
GraphPCA: a fast and interpretable dimension reduction algorithm for spatial transcriptomics data
The rapid advancement of spatial transcriptomics technologies has revolutionized our
understanding of cell heterogeneity and intricate spatial structures within tissues and …
understanding of cell heterogeneity and intricate spatial structures within tissues and …
SOFisher: Reinforcement Learning-Guided Experiment Designs for Spatial Omics
Z Li, W Wu, Y Cui, S Jian, Z Yuan - bioRxiv, 2024 - biorxiv.org
Spatial omics technologies enable the precise detection of proteins and RNAs at high
spatial resolution. Designing spatial omics experiments requires careful consideration of" …
spatial resolution. Designing spatial omics experiments requires careful consideration of" …
Identifying Differential Spatial Expression Patterns across Different Slices, Conditions and Developmental Stages with Interpretable Deep Learning
Y Cui, Z Yuan - bioRxiv, 2024 - biorxiv.org
Spatially resolved transcriptomics technologies enable the map** of multiplexed gene
expression profiles within tissue contexts. To explore the gene spatial patterns in complex …
expression profiles within tissue contexts. To explore the gene spatial patterns in complex …
[PDF][PDF] The Role of Scar-Associated Macrophages in Liver Fibrosis
D Ma - en.front-sci.com
Liver fibrosis is a critical condition closely linked to liver cirrhosis and hepatocellular
carcinoma, primarily due to the accumulation of extracellular matrix proteins produced by …
carcinoma, primarily due to the accumulation of extracellular matrix proteins produced by …