Apoptosis and apoptotic body: disease message and therapeutic target potentials

X Xu, Y Lai, ZC Hua - Bioscience reports, 2019 - portlandpress.com
Apoptosis is widely known as programmed cell death eliciting no inflammatory responses.
The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth …

[HTML][HTML] Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products

Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives

E Khatoon, K Banik, C Harsha, BL Sailo… - Seminars in Cancer …, 2022 - Elsevier
Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …

[HTML][HTML] CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p–XIAP axis

J Shang, WM Chen, ZH Wang, TN Wei, ZZ Chen… - Experimental …, 2019 - Elsevier
The contribution and role of circular RNAs (circRNAs) in mediating chemoresistance in
acute myeloid leukemia (AML) are still poorly understood and need further investigation. In …

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

BA Tayeb, IY Kusuma, AAM Osman… - Journal of Integrative …, 2024 - Elsevier
Background The field of personalized medicine has gained increasing attention in cancer
care, with the aim of tailoring treatment strategies to individual patients for improved …

[HTML][HTML] Curcumin-mediated apoptotic cell death in papillary thyroid cancer and cancer stem-like cells through targeting of the JAK/STAT3 signaling pathway

AQ Khan, EI Ahmed, N Elareer, H Fathima… - International journal of …, 2020 - mdpi.com
The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription
(JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related …

Pectolinarigenin induced cell cycle arrest, autophagy, and apoptosis in gastric cancer cell via PI3K/AKT/mTOR signaling pathway

HJ Lee, V Venkatarame Gowda Saralamma, SM Kim… - Nutrients, 2018 - mdpi.com
Pectolinarigenin (PEC), a natural flavonoid present in Cirsium chanroenicum and in some
species of Citrus fruits, has various pharmacological benefits such as anti-inflammatory and …

A comprehensive insight on the biological potential of embelin and its derivatives

NJ Basha, SM Basavarajaiah, S Baskaran… - Natural Product …, 2022 - Taylor & Francis
Naturally occurring bioactive molecules are known for their diverse biological applications
such as antimicrobial, anticancer, anti-inflammatory, and analgesic activities. Also, some of …

[HTML][HTML] The application of embelin for cancer prevention and therapy

JH Ko, SG Lee, WM Yang, JY Um, G Sethi, S Mishra… - Molecules, 2018 - mdpi.com
Embelin is a naturally-occurring benzoquinone compound that has been shown to possess
many biological properties relevant to human cancer prevention and treatment, and …

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans

KS Prabhu, F Ahmad, S Kuttikrishnan, R Leo… - Cell Death …, 2024 - nature.com
Non-melanoma skin cancer (NMSC), encompassing basal and squamous cell carcinoma, is
the most prevalent cancer in the United States. While surgical removal remains the …