Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …