Immune regulation by glucocorticoids
DW Cain, JA Cidlowski - Nature Reviews Immunology, 2017 - nature.com
Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …
Pathogen recognition and inflammatory signaling in innate immune defenses
TH Mogensen - Clinical microbiology reviews, 2009 - Am Soc Microbiol
The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …
[HTML][HTML] The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
AE Coutinho, KE Chapman - Molecular and cellular endocrinology, 2011 - Elsevier
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …
inflammatory effects, they have been amongst the most widely used and effective treatments …
MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response
Monocytes and macrophages are important components of the immune system, specialized
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
One hormone, two actions: anti-and pro-inflammatory effects of glucocorticoids
D Cruz-Topete, JA Cidlowski - Neuroimmunomodulation, 2014 - karger.com
Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response
to stress. Since their discovery in the 1940s, glucocorticoids have been widely prescribed to …
to stress. Since their discovery in the 1940s, glucocorticoids have been widely prescribed to …
Control of immunity by glucocorticoids in health and disease
A Shimba, K Ikuta - Seminars in Immunopathology, 2020 - Springer
Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …
New insights into the cell-and tissue-specificity of glucocorticoid actions
Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the
organism and adaptation to the external environment. Because of their anti-inflammatory …
organism and adaptation to the external environment. Because of their anti-inflammatory …
Dual‐specificity MAP kinase phosphatases (MKPs) Sha** the outcome of MAP kinase signalling
Dual‐specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory
network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase …
network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase …
More than suppression: glucocorticoid action on monocytes and macrophages
JM Ehrchen, J Roth, K Barczyk-Kahlert - Frontiers in immunology, 2019 - frontiersin.org
Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …