Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and
usually has its onset during youth. Its chronic course is associated with high rates of …

Objectives: Although clinically highly relevant, the recognition and treatment of bipolar mixed
states has played only an underpart in recent guidelines. This WFSBP guideline has been …

INTRODUCTION Co** with negative experience is essential for survival. Animals must
quickly recognize a harmful situation, produce an adequate response, and learn its context …

Objective This systematic review provided a critical synthesis and a comprehensive
overview of guidelines on the treatment of mixed states. Method The MEDLINE/PubMed and …

The identification of mixed features in bipolar disorder (BD) and major depressive disorder
(MDD) is an open challenge in psychiatry, because an accurate diagnosis is a prerequisite …

Substance use disorder (SUD) is a common comorbidity in individuals with bipolar disorder
(BD), and it is associated with a severe course of illness, making early identification of the …

The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in
neurobehavioral research. Aggression is a common symptom of many CNS disorders, has …

Aggressive behavior (AB) represents a public health concern often associated with severe
psychiatric disorders. Although most psychiatric patients are not aggressive, untreated …

Trazodone is indicated for the treatment of depression and has been shown efficacious in
reducing most symptoms associated with depressioná1-3. The peculiar multifunctional …

Abstract According to the DSM-5,“reduction in the need for sleep” is the only sleep-related
criteria for mixed features in depressive episodes. We aimed at studying the prevalence …