Nitrogen-fixing organelle in a marine alga

TH Coale, V Loconte, KA Turk-Kubo, B Vanslembrouck… - Science, 2024 - science.org
Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles,
which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the …

Soft X‐ray tomograms provide a structural basis for whole‐cell modeling

V Loconte, JH Chen, B Vanslembrouck… - The FASEB …, 2023 - Wiley Online Library
Develo** in silico models that accurately reflect a whole, functional cell is an ongoing
challenge in biology. Current efforts bring together mathematical models, probabilistic …

Emergent actin flows explain distinct modes of gliding motility

CL Hueschen, L Segev-Zarko, JH Chen, MA LeGros… - Nature Physics, 2024 - nature.com
During host infection, Toxoplasma gondii and related unicellular parasites move using
gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility …

Correlative single-cell hard X-ray computed tomography and X-ray fluorescence imaging

Z Lin, X Zhang, P Nandi, Y Lin, L Wang, YS Chu… - Communications …, 2024 - nature.com
X-ray computed tomography (XCT) and X-ray fluorescence (XRF) imaging are two non-
invasive imaging techniques to study cellular structures and chemical element distributions …

Maximizing microbial bioproduction from sustainable carbon sources using iterative systems engineering

T Eng, D Banerjee, J Menasalvas, Y Chen, J Gin… - Cell Reports, 2023 - cell.com
Maximizing the production of heterologous biomolecules is a complex problem that can be
addressed with a systems-level understanding of cellular metabolism and regulation …

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

S Boeynaems, XR Ma, V Yeong, GM Ginell, JH Chen… - BioRxiv, 2023 - pmc.ncbi.nlm.nih.gov
Positively charged repeat peptides are emerging as key players in neurodegenerative
diseases. These peptides can perturb diverse cellular pathways but a unifying framework for …

Automated 3D cytoplasm segmentation in soft X-ray tomography

A Erozan, PD Lösel, V Heuveline, V Weinhardt - Iscience, 2024 - cell.com
Cells' structure is key to understanding cellular function, diagnostics, and therapy
development. Soft X-ray tomography (SXT) is a unique tool to image cellular structure …

[HTML][HTML] Soft X-ray tomography reveals HSV-1-induced remodeling of human B cells

JH Chen, B Vanslembrouck, A Ekman, V Aho… - Viruses, 2022 - mdpi.com
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize
them for viral proliferation. Since viruses are about a thousand times smaller than their host …

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

S Leclerc, V Ruokolainen, A Gupta, A Ekman… - Biophysical …, 2024 - cell.com
Viruses target mitochondria to promote viral replication, and infection-induced stress during
the progression of infection leads to the regulation of antiviral defenses and mitochondrial …

Laboratory based correlative cryo-soft X-ray tomography and cryo-fluorescence microscopy

K Fahy, S Kapishnikov, M Donnellan… - Methods in cell …, 2024 - books.google.com
Cryo-soft X-ray tomography is the unique technology that can image whole intact cells in 3D
under normal and pathological conditions without labelling or fixation, at high throughput …