Inflammation drives pathology in many human diseases for which there are no disease-
modifying drugs. Inflammasomes are signalling platforms that can induce pathological …

Ischemic stroke, a primary cause of disability and the second leading cause of mortality, has
emerged as an urgent public health issue. Growing evidence suggests that the Cyclic GMP …

The risk of early recurrent events after stroke remains high despite currently established
secondary prevention strategies. Risk is particularly high in patients with atherosclerosis …

Ischemic stroke (IS) is a significant global public health issue with a high incidence,
disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging …

Macrophages play a central role in antitumor immunity, making them an attractive target for
gene therapy strategies. However, macrophages are difficult to transfect because of nucleic …

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by
recurrent inflammatory lesions, which affect skin and hair follicles in intertriginous areas. HS …

AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded
DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of …

Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …

The cardiovascular complications of atherosclerosis are thought to arise from an
inflammatory response to the accumulation of cholesterol-rich lipoproteins in the arterial …

Ischemic stroke is the most common cerebrovascular disease and the leading cause of
permanent disability worldwide. Recent studies have shown that stroke development and …