The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …

Background Frailty is a medical syndrome that is strongly associated with mortality risk and
an emerging global health burden. Mental disorders are associated with reduced life …

Individual-level studies with adjustment for important COVID-19 risk factors suggest positive
associations of long-term air pollution exposure (particulate matter and nitrogen dioxide) …

Biological age captures physiological deterioration better than chronological age and is
amenable to interventions. Blood-based biomarkers have been identified as suitable …

Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

The plasma proteome can mediate associations between periodontal disease (Pd) and
brain white matter integrity (WMI). We screened 5089 UK Biobank participants aged 40–70 …

We have developed a deep learning aging clock using blood test data from the China
Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years …

Modern Western biomedical research and clinical practice are primarily focused on disease.
This disease-centric approach has yielded an impressive amount of knowledge around what …

Background Long-term exposure to air pollution concentrations is known to be adversely
associated with a broad range of single non-communicable diseases, but its role in …

Background Cardiovascular health is associated with brain magnetic resonance imaging
(MRI) markers of pathology and infections may modulate this association. Methods Using …