Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

It is well known that many tumours are potentially immunogenic, as corroborated by the
presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

MHC class I molecules function to present peptides eight to ten residues long to the immune
system. These peptides originate primarily from a cytosolic pool of proteins through the …

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now
known to represent a distinct member of the IFN family and plays critical roles not only in …

Cervical cancer is responsible for 10–15% of cancer-related deaths in women worldwide,.
The aetiological role of infection with high-risk human papilloma viruses (HPVs) in cervical …

Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …

Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that
are recognized by a subset of γδ T cells expressing the variable region Vδ1. This functional …