Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of …

DNA methylation is an epigenetic modification that has critical roles in gene silencing,
development and genome integrity. In Arabidopsis, DNA methylation is established by …

ChIP-Seq (chromatin immunoprecipitation sequencing) has provided the advantage for
finding motifs as ChIP-Seq experiments narrow down the motif finding to binding site …

Lineage-specific stem cells are critical for the production and maintenance of specific cell
types and tissues in multicellular organisms. In Arabidopsis, the initiation and proliferation of …

The plant-specific DNA-dependent RNA polymerase V (Pol V) evolved from Pol II to function
in an RNA-directed DNA methylation pathway. Here, we have identified targets of Pol V in …

IHF and HU are two heterodimeric nucleoid-associated proteins (NAP) that belong to the
same protein family but interact differently with the DNA. IHF is a sequence-specific DNA …

Background Binding of transcription factors to transcription factor binding sites (TFBSs) is
key to the mediation of transcriptional regulation. Information on experimentally validated …

The orphan, atypical response regulators BldM and WhiI each play critical roles in
Streptomyces differentiation. BldM is required for the formation of aerial hyphae, and WhiI is …

Actin has been linked to processes spanning the whole gene expression cascade, from
regulating specific transcription factors, such as myocardin-related transcription factor, to …

The DNA damage response is crucial for bacterial survival. The transcriptional repressor
LexA is a key component of the SOS response, the main mechanism for the regulation of …