Abstract α 2 δ proteins are membrane-anchored extracellular glycoproteins which are
abundantly expressed in the brain and the peripheral nervous system. They serve as …

Neuropathic pain (NP) is a chronic pain caused by injury or disease of the somatosensory
nervous system, or it can be directly caused by disease. It often presents with clinical …

Neurotransmitter release consists of rapid synchronous release followed by longer-lasting
asynchronous release (AR). Although the presynaptic proteins that trigger synchronous …

Elongation of very long fatty acids-4 (ELOVL4) mediates biosynthesis of very long chain-fatty
acids (VLC-FA;≥ 28 carbons). Various mutations in this enzyme result in spinocerebellar …

In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have
been linked to synaptic functions and neurological disease. Here we show that α2δ subunits …

In contrast to their postsynaptic counterparts, the contributions of activity-dependent
cytoskeletal signaling to presynaptic plasticity remain controversial and poorly understood …

The α2δ auxiliary subunits of voltage-gated calcium channels (VGCC) were traditionally
regarded as modulators of biophysical channel properties. In recent years, channel …

Spinocerebellar ataxias are neurodegenerative diseases, the hallmark symptom of which is
the development of ataxia due to cerebellar dysfunction. Purkinje cells, the principal neurons …

L-type voltage-gated calcium (Ca2+) channels (L-VGCC) dysfunction is implicated in several
neurological and psychiatric diseases. While a popular therapeutic target, it is unknown …

Abstract α2δ proteins serve as auxiliary subunits of voltage‐gated calcium channels and
regulate channel membrane expression and current properties. Besides their channel …