Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator
of activation, differentiation, and migration processes in various cell types. In this review, we …

T helper 2 (Th2) responses protect against pathogens while also driving allergic
inflammation, yet how large-scale Th2 responses are generated in tissue context remains …

Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-
spectrum response before adopting bespoke cytokine expression profiles shaped by …

T cells experience complex temporal patterns of stimulus via receptor–ligand-binding
interactions with surrounding cells. From these temporal patterns, T cells are able to pick out …

Immune cells are highly dynamic and able to migrate through environments with diverse
biochemical and mechanical compositions. Their migration has classically been defined as …

The extracellular matrix (ECM) is extensively remodeled during inflammation providing
essential guidance cues for immune cell migration and signals for cell activation and …

Primary brain tumors are a leading cause of death worldwide and are characterized by
extraordinary heterogeneity and high invasiveness. Current drug and radiotherapy therapies …

The insensitivity of multiphoton microscopy to optical scattering enables high-resolution,
high-contrast imaging deep into tissue, including in live animals. Scattering does, however …

Intracellular phagosomal pathogens represent a formidable challenge for innate immune
cells, as, paradoxically, these phagocytic cells can act as both host cells that support …