Zinc-finger proteins in health and disease
M Cassandri, A Smirnov, F Novelli, C Pitolli… - Cell death …, 2017 - nature.com
Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Y Abuetabh, HH Wu, C Chai, H Al Yousef… - … & molecular medicine, 2022 - nature.com
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
The multiple mechanisms of MCL1 in the regulation of cell fate
Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
H Rottenberg, JB Hoek - Aging cell, 2017 - Wiley Online Library
Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …
[HTML][HTML] The impact of toxic metal bioaccumulation on colorectal cancer: Unravelling the unexplored connection
Colorectal cancer is a major public health concern, with increasing incidence and mortality
rates worldwide. Environmental factors, including exposure to toxic metals, such as lead …
rates worldwide. Environmental factors, including exposure to toxic metals, such as lead …
Therapeutic effects of EGCG: a patent review
L Chakrawarti, R Agrawal, S Dang… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Green tea contains polyphenolic flavanoids such as epigallocatechin-3-gallate
(EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). EGCG …
(EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). EGCG …
Nrf2: Molecular and epigenetic regulation during aging
A Silva-Palacios, M Ostolga-Chavarría, C Zazueta… - Ageing research …, 2018 - Elsevier
Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …
[HTML][HTML] DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
F Ciccarone, S Tagliatesta, P Caiafa… - Mechanisms of ageing …, 2018 - Elsevier
DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …
predicting life expectancy. However, the mechanisms underlying age-related DNA …
White shark genome reveals ancient elasmobranch adaptations associated with wound healing and the maintenance of genome stability
The white shark (Carcharodon carcharias; Chondrichthyes, Elasmobranchii) is one of the
most publicly recognized marine animals. Here we report the genome sequence of the white …
most publicly recognized marine animals. Here we report the genome sequence of the white …
Exercise effects on physiological function during aging
The decrease in cognitive/motor functions and physical abilities severely affects the aging
population in carrying out daily activities. These disabilities become a burden on individuals …
population in carrying out daily activities. These disabilities become a burden on individuals …