The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the slee**
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates
thalamocortical interactions that are critical for sensory processing, attention and cognition 1 …

Emotion regulation is hypothesized to be a multifaceted process by which individuals
willfully modulate the intensity and direction of emotional response via prefrontally mediated …

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding …

Combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG)
constitutes a powerful tool to directly assess human cortical excitability and connectivity …

The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

During non-rapid eye movement (NREM) sleep, synchronous synaptic activity in the
thalamocortical network generates predominantly low-frequency oscillations (< 4 Hz) that …