Developments in hydrogen/deuterium exchange mass spectrometry
Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …
through June 2014 and described the publications in terms of sector, geography, and topic …
Small-angle X-ray scattering studies of enzymes
Enzyme function requires conformational changes to achieve substrate binding, domain
rearrangements, and interactions with partner proteins, but these movements are difficult to …
rearrangements, and interactions with partner proteins, but these movements are difficult to …
A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells
The molecular mechanisms and forces involved in the translocation of bacterial toxins into
host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from …
host cells are still a matter of intense research. The adenylate cyclase (CyaA) toxin from …
Perspectives on solution-based small angle X-ray scattering for protein and biological macromolecule structural biology
Small-angle X-rays scattering (SAXS) is used to extract structural information from a wide
variety of non-crystalline samples in different fields (eg, materials science, physics …
variety of non-crystalline samples in different fields (eg, materials science, physics …
Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis
Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate
cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by …
cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by …
Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats
Abstract Human Long Intergenic Noncoding RNA-p21 (LincRNA-p21) is a regulatory
noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also …
noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also …
Post‐translational acylation controls the folding and functions of the CyaA RTX toxin
DP O'Brien, SE Cannella, A Voegele… - The FASEB …, 2019 - Wiley Online Library
The adenylate cyclase (CyaA) toxin is a major virulence factor of Bordetella pertussis, the
causative agent of whoo** cough. CyaA is synthetized as a pro‐toxin, pro‐CyaA, and …
causative agent of whoo** cough. CyaA is synthetized as a pro‐toxin, pro‐CyaA, and …
Interpreting hydrogen-deuterium exchange experiments with molecular simulations: Tutorials and applications of the HDXer ensemble reweighting software [Article v1 …
Hydrogen-deuterium exchange (HDX) is a comprehensive yet detailed probe of protein
structure and dynamics and, coupled to mass spectrometry, has become a powerful tool for …
structure and dynamics and, coupled to mass spectrometry, has become a powerful tool for …
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella
pertussis, the causative agent of whoo** cough. CyaA is able to invade eukaryotic cells …
pertussis, the causative agent of whoo** cough. CyaA is able to invade eukaryotic cells …
[Free GPT-4]
Many cellular functions necessitate structural assemblies of two or more associated proteins.
The structural characterization of protein complexes using standard methods, such as X-ray …
The structural characterization of protein complexes using standard methods, such as X-ray …