Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Functional cellular heterogeneity in tumours often underlies incomplete response to therapy
and relapse. Previously, we demonstrated that the growth of the paediatric brain …

Developmental abnormalities of the cerebellum are among the most recognized structural
brain malformations in human prenatal imaging. Yet reliable information regarding their …

Background Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells
and associated immune cells contribute to disease progression. We aimed to determine the …

OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic
Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific …

Cancer treatments always face challenging problems, particularly drug resistance due to
tumor cell heterogeneity. The existing datasets include the relationship between gene …

Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …

Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the
single-cell level that has been widely used due to its unprecedented high resolution. In the …

Malignant brain tumors rank among the most challenging type of malignancies to manage.
The current treatment protocol commonly entails surgery followed by radiotherapy and/or …