Background The initiating nucleotide found at the 5'end of primary transcripts has a
distinctive triphosphorylated end that distinguishes these transcripts from all other RNA …

The NAD-dependent histone deacetylase Sirt1 is a negative regulator of T cell activation.
Here we report that Sirt1 inhibits T cell activation by suppressing the transcription of Bcl2 …

It is well established that the small GTPase Ras promotes tumor initiation by activating at
least three different mediators: Raf, PI3K, and Ras-like (Ral) guanine nucleotide exchange …

The structure, dynamics and, ultimately, biological function of proteins and nucleic acids are
determined by the physicochemical properties of their primary sequences. Such properties …

One prominent pattern of mutational frequency, long appreciated in comparative genomics,
is the bias of purine/pyrimidine conserving substitutions (transitions) over purine/pyrimidine …

Despite our long familiarity with how the genetic code specifies the amino acid sequence,
we still know little about why it is organized in the way that it is. Contrary to the view that the …

In eukaryotic cells, DNA associates with histones and exists in the form of a chromatin
hierarchy. Thus, it is generally believed that many eukaryotic cellular DNA processing …

10–11bp repeating patterns of the particular dinucleotides were suggested in positioning
nucleosomes in eukaryotes. In order to assess the role, the 10–11bp periodicities of the …

Posttranslational modifications of histones belong to epigenetic mechanisms that regulate
gene expression by chromatin structure changes. Generally, histone acetylation reduces its …

Abstract Background Transcription start sites (TSSs) with pronounced and phased
nucleosome arrays downstream and nucleosome-depleted regions upstream of TSSs are …