Mechanical regulation of chromatin and transcription
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
Cell–3D matrix interactions: recent advances and opportunities
KM Yamada, AD Doyle, J Lu - Trends in cell biology, 2022 - cell.com
Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …
Matrix viscoelasticity controls spatiotemporal tissue organization
Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …
The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
Sculpting tissues by phase transitions
PF Lenne, V Trivedi - Nature Communications, 2022 - nature.com
Biological systems display a rich phenomenology of states that resemble the physical states
of matter-solid, liquid and gas. These phases result from the interactions between the …
of matter-solid, liquid and gas. These phases result from the interactions between the …
Unravelling cell migration: defining movement from the cell surface
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
Robust phenoty** of highly multiplexed tissue imaging data using pixel-level clustering
While technologies for multiplexed imaging have provided an unprecedented understanding
of tissue composition in health and disease, interpreting this data remains a significant …
of tissue composition in health and disease, interpreting this data remains a significant …
Extracellular matrix mechanobiology in cancer cell migration
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
Intrinsic mechanical cues and their impact on stem cells and embryogenesis
J Petzold, E Gentleman - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …
of cell biology in the second half of the 20th century, over the last two decades, new insights …
Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine
N **e, C **ao, Q Shu, B Cheng, Z Wang, R Xue, Z Wen… - Acta Biomaterialia, 2023 - Elsevier
Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …
properties, stretching, compression and shear stress, play a critical role in maintaining …