Multivalent glycans for biological and biomedical applications

Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2021 - pubs.rsc.org
Recognition of glycans by proteins plays a crucial role in a variety of physiological
processes in cells and living organisms. In addition, interactions of glycans with proteins are …

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

M Kaurav, S Ruhi, HA Al-Goshae, AK Jeppu… - Frontiers in …, 2023 - frontiersin.org
A brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that
grow and divide abnormally and appear to be uncontrollable by the processes that normally …

Multivalent sialic acid materials for biomedical applications

Y Cao, W Song, X Chen - Biomaterials Science, 2023 - pubs.rsc.org
Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …

Expanding the scope of stereoselective α-galactosylation using glycosyl chlorides

M Shadrick, KJ Stine, AV Demchenko - Bioorganic & medicinal chemistry, 2022 - Elsevier
Recently, we reported that silver (I) oxide mediated Koenigs-Knorr glycosylation reaction
can be dramatically accelerated in the presence of catalytic acid additives. We have also …

Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

C García-Oliva, A Merchán, A Perona… - New Journal of …, 2022 - pubs.rsc.org
Two green strategies for copper-catalyzed azide–alkyne cycloaddition reaction based on
two activation pathways, solvent free mechanochemistry and microwave irradiation using a …

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

I Rodríguez‐Izquierdo… - Wiley …, 2022 - Wiley Online Library
Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy,
most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 …

Mechanistic Studies for the Rational Design of Multivalent Glycodendrimers

Y Manabe, M Tsutsui, K Hirao… - … A European Journal, 2022 - Wiley Online Library
We have synthesized B‐antigen‐displaying dendrimers (16‐mers) with different sizes and
evaluated their affinity to their IgM antibody in order to investigate which design features …

Building synergistic nanoplatforms via dendrimer-small organic molecule handshakes: Heterocycle ligation as a promising strategy

CR Nair, KG Sreejalekshmi - Materials Today Chemistry, 2024 - Elsevier
Branching out in a cascade fashion from a central core and presenting multivalent
cooperativity, dendrimers, with their well-defined architecture, received significant attention …

Thiol-Ene Click-Inspired Late-Stage Modification of Long-Chain Polyurethane Dendrimers

DP Poudel, RT Taylor - Reactions, 2021 - mdpi.com
The construction of well-defined polyurethane dendrimers is challenging due to the high
reactivity of externally added or in situ formed isocyanates leading to the formation of side …

[PDF][PDF] Synthetic Study of Bio-functional Glycans

K Fukase, A Shimoyama, Y Manabe - Modern Natural Product …, 2024 - library.oapen.org
The molecular structures responsible for the immune functions of complex glycans were
unraveled by synthetic studies. We focused on develo** efficient methods for synthesizing …