Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …

Cryptococcosis is an infectious disease caused by the encapsulated fungi Cryptococcus
neoformans and Cryptococcus gattii. Cryptococcal infection can develop in apparently …

Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

Despite improvement of antifungal therapies over the last 30 years, the phenomenon of
antifungal resistance is still of major concern in clinical practice. In the last 10 years the …

Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Acanthamoeba is an opportunistic protozoan that is widely distributed in the environment
and is well recognized to produce serious human infections, including a blinding keratitis …

Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …