Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update
K Engle, G Kumar - European journal of medicinal chemistry, 2022 - Elsevier
Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies
Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
Phenylazothiazoles as visible-light photoswitches
A novel class of photoswitches based on a phenylazothiazole scaffold that undergoes
reversible isomerization under visible-light irradiation is reported. The photoswitch, which …
reversible isomerization under visible-light irradiation is reported. The photoswitch, which …
Comprehensive insights into medicinal research on imidazole-based supramolecular complexes
SR Li, YM Tan, L Zhang, CH Zhou - Pharmaceutics, 2023 - mdpi.com
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …
nitrogen atoms, is an important functional fragment widely present in a large number of …
Development of membrane-targeting fluorescent 2-phenyl-1 h-phenanthro [9, 10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant …
T Xu, X Yan, A Kang, L Yang, X Li, Y Tian… - Journal of Medicinal …, 2024 - ACS Publications
The escalation of multidrug-resistant bacterial infections, especially infections caused by
methicillin-resistant Staphylococcus aureus (MRSA), underscores the urgent need for novel …
methicillin-resistant Staphylococcus aureus (MRSA), underscores the urgent need for novel …
Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …
Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational …
In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …
Semistabilized Diazatrienyl Anions from Pyridine Imines and Acetylenes: An Access to (Z)-Stilbene/Imidazopyridine Ensembles, Benzyl Imidazopyridines, and …
IA Bidusenko, EY Schmidt, IA Ushakov… - The Journal of …, 2022 - ACS Publications
Semistabilized diazatrienyl anions are generated by the reaction of 2-pyridylarylimines with
arylacetylenes in superbase systems MO t Bu (M= Li, Na, K)/DMSO at ambient temperature …
arylacetylenes in superbase systems MO t Bu (M= Li, Na, K)/DMSO at ambient temperature …
Synthesis, in silico prediction and in vitro evaluation of antimicrobial activity, dft calculation and theoretical investigation of novel xanthines and uracil containing …
Novel xanthine and imidazolone derivatives were synthesized based on oxazolone
derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone …
derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone …
Synthesis, characterization, SC-XRD, HSA and DFT study of a novel copper (I) iodide complex with 2-(thiophen-2-yl)-4, 5-dihydro-1H-imidazole ligand: An …
The reaction of 2-cyanothiophene with ethylenediamine under the irradiation of ultrasound
waves produces a new imidazole ligand (L). The reaction of this ligand with copper (I) iodide …
waves produces a new imidazole ligand (L). The reaction of this ligand with copper (I) iodide …