Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update

K Engle, G Kumar - European journal of medicinal chemistry, 2022 - Elsevier
Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

M Koley, J Han, VA Soloshonok… - RSC medicinal …, 2023 - pmc.ncbi.nlm.nih.gov
Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …

Phenylazothiazoles as visible-light photoswitches

R Lin, PK Hashim, S Sahu, AS Amrutha… - Journal of the …, 2023 - ACS Publications
A novel class of photoswitches based on a phenylazothiazole scaffold that undergoes
reversible isomerization under visible-light irradiation is reported. The photoswitch, which …

Comprehensive insights into medicinal research on imidazole-based supramolecular complexes

SR Li, YM Tan, L Zhang, CH Zhou - Pharmaceutics, 2023 - mdpi.com
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …

Development of membrane-targeting fluorescent 2-phenyl-1 h-phenanthro [9, 10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant …

T Xu, X Yan, A Kang, L Yang, X Li, Y Tian… - Journal of Medicinal …, 2024 - ACS Publications
The escalation of multidrug-resistant bacterial infections, especially infections caused by
methicillin-resistant Staphylococcus aureus (MRSA), underscores the urgent need for novel …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational …

M Devi, P Kumar, R Singh, J Sindhu… - European Journal of …, 2023 - Elsevier
In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …

Semistabilized Diazatrienyl Anions from Pyridine Imines and Acetylenes: An Access to (Z)-Stilbene/Imidazopyridine Ensembles, Benzyl Imidazopyridines, and …

IA Bidusenko, EY Schmidt, IA Ushakov… - The Journal of …, 2022 - ACS Publications
Semistabilized diazatrienyl anions are generated by the reaction of 2-pyridylarylimines with
arylacetylenes in superbase systems MO t Bu (M= Li, Na, K)/DMSO at ambient temperature …

Synthesis, in silico prediction and in vitro evaluation of antimicrobial activity, dft calculation and theoretical investigation of novel xanthines and uracil containing …

S El-Kalyoubi, F Agili, WA Zordok… - International Journal of …, 2021 - mdpi.com
Novel xanthine and imidazolone derivatives were synthesized based on oxazolone
derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone …

Synthesis, characterization, SC-XRD, HSA and DFT study of a novel copper (I) iodide complex with 2-(thiophen-2-yl)-4, 5-dihydro-1H-imidazole ligand: An …

H Kargar, M Ashfaq, M Fallah-Mehrjardi… - Journal of Molecular …, 2022 - Elsevier
The reaction of 2-cyanothiophene with ethylenediamine under the irradiation of ultrasound
waves produces a new imidazole ligand (L). The reaction of this ligand with copper (I) iodide …