Parthanatos is a PARP1-dependent, caspase-independent, cell-death pathway that is
distinct from apoptosis, necrosis, or other known forms of cell death. Parthanatos is a …

Over 17,000 papers related to proteomics have been published since our 2011− 2013
review. A subset are true gems reporting amazing applications of proteomics to better …

Opioid receptors belong to the class AG‐protein‐coupled receptors and are activated by
alkaloid opiates such as morphine, and endogenous ligands such as endorphins and …

Neuroblastoma (NB) is the most frequent extracranial pediatric tumor. Despite the current
available multiple therapeutic options, the prognosis for high-risk NB patients remains …

Background Phosphorylation is an important regulatory mechanism of protein activity in
cells. Studies in various cancers have reported perturbations in kinases resulting in aberrant …

Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic
alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK …

Gemcitabine is an effective chemotherapeutic agent for biliary tract cancers (BTCs),
including gallbladder cancer (GBC) and cholangiocarcinoma (CCA). However, few other …

This study sought to investigate the biological effects of specific MIF inhibitor, ISO-1, on the
proliferation, migration and invasion of PANC-1 human pancreatic cells in vitro, and on …

Macrophage migration inhibitory factor (MIF) is a prominent orchestrator during the onset
and progression of cancer. Recently, MIF was detected in salivary adenoid cystic carcinoma …

Orexins are excitatory neuropeptides, which are predominantly associated with feeding
behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of …